Mechanisms of action

Over the past four decades, it was theorised that Biomagnetic pair therapy helps neutralise the body’s pH levels, building a hostile environment to pathogens. Recent empirical evidence has established that static magnetic fields (magnets therapists use in Biomagnetism sessions) provide a myriad of mechanisms of action. One relevant mechanism of action resides in the influence of biological processes at the cellular and molecular levels [1]. Static magnetic fields straighten the phospholipid bilayer of the cell membrane [Figure 1]. As a consequence, transmembrane proteins change conformation, allowing them to become more efficient (more active) in transporting ions through the phospholipid cell membrane [Figure 2].

Figure 1

The phospholipids straightened after exposure to static magnetic fields - Illustration was taken with permission.

Figure 2

The ion channels become more active with SMF. The illustration was taken with permission.

This efficiency in the transmembrane proteins is highly relevant, especially in calcium channels which control the gene expression of cytokines such as Interleukin 6 [2]. Research evidence has demonstrated that Interleukin 6 is involved in immune response [3,4], tissue regeneration [5,6,7] and the formation of the intestinal epithelial barrier [8]. The formation of the epithelial barrier in the intestines is crucial for maintaining gut homeostasis and protecting the body from harmful substances while allowing the absorption of nutrients [9].

Learn about other mechanisms of action

References

Zhang X, Yarema K, Xu A, Zhang X, Yarema K, Xu A. Molecular Mechanisms for Electromagnetic Field Biosensing. Biological Effects of Static Magnetic Fields. 2017:51-79.
Wang Z, Sarje A, Che P-L, Yarema KJ. Moderate strength (0.23–0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells. BMC genomics. 2009;10:1-23.
Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;6(10):a016295.
Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, et al. IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. The Journal of Immunology. 2013;190(2):703-11.
Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science. 1996;274(5291):1379-83.
Galun E, Zeira E, Pappo O, Peters M, Rose-John S. Liver regeneration induced by a designer human IL‐6/sIL‐6R fusion protein reverses severe hepatocellular injury. The FASEB Journal. 2000;14(13):1979-87.
Kuhn KA, Manieri NA, Liu T-C, Stappenbeck TS. IL-6 stimulates intestinal epithelial proliferation and repair after injury. PloS one. 2014;9(12):e114195.
Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, et al. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunology. 2018;11(2):357-68
Rios-Arce ND, Collins FL, Schepper JD, Steury MD, Raehtz S, Mallin H, et al. Epithelial Barrier Function in Gut-Bone Signaling. Adv Exp Med Biol. 2017;1033:151-83.

Mechanisms of action

Figure 1

Figure 2

Learn about other mechanisms of action

References

Zhang X, Yarema K, Xu A, Zhang X, Yarema K, Xu A. Molecular Mechanisms for Electromagnetic Field Biosensing. Biological Effects of Static Magnetic Fields. 2017:51-79.

Wang Z, Sarje A, Che P-L, Yarema KJ. Moderate strength (0.23–0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells. BMC genomics. 2009;10:1-23.

Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;6(10):a016295.

Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, et al. IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. The Journal of Immunology. 2013;190(2):703-11.

Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science. 1996;274(5291):1379-83.

Galun E, Zeira E, Pappo O, Peters M, Rose-John S. Liver regeneration induced by a designer human IL‐6/sIL‐6R fusion protein reverses severe hepatocellular injury. The FASEB Journal. 2000;14(13):1979-87.

Kuhn KA, Manieri NA, Liu T-C, Stappenbeck TS. IL-6 stimulates intestinal epithelial proliferation and repair after injury. PloS one. 2014;9(12):e114195.

Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, et al. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunology. 2018;11(2):357-68

Rios-Arce ND, Collins FL, Schepper JD, Steury MD, Raehtz S, Mallin H, et al. Epithelial Barrier Function in Gut-Bone Signaling. Adv Exp Med Biol. 2017;1033:151-83.